Neurobiology of Disease Urokinase-Type Plasminogen Activator Promotes Dendritic Spine Recovery and Improves Neurological Outcome Following Ischemic Stroke

Fang Wu,1* Marcela Catano,1* Ramiro Echeverry,1* Enrique Torre,1 Woldeab B. Haile,1 Jie An,1,2 Changhua Chen,1 Lihong Cheng,1 Andrew Nicholson,3 Frank C. Tong,4 Jaekeun Park,5 and X Manuel Yepes1,6 1Department of Neurology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia 30322, 2Department of Pharmacology, Shandong University School of Medicine, 250100 Jinan, China, 3Department of Radiology and Imaging Sciences and 4Departments of Radiology and Neurosurgery, Emory University School of Medicine, Atlanta, Georgia 30322, 5Wallace H. Coulter Department of Biomedical Engineering, Emory University, Atlanta, Georgia 30322, and 6Department of Neurology, Veterans Affairs Medical Center, Atlanta, Georgia 30349